Experimentation has been critical and increasingly popular across various domains, such as clinical trials and online platforms, due to its widely recognized benefits. One of the primary objectives of classical experiments is to estimate the average treatment effect (ATE) to inform future decision-making. However, in healthcare and many other settings, treatment effects may be non-stationary, meaning that they can change over time, rendering the traditional experimental design inadequate and the classical static ATE uninformative. In this work, we address the problem of non-stationary experimental design under linear trends by considering two objectives: estimating the dynamic treatment effect and minimizing welfare loss within the experiment. We propose an efficient design that can be customized for optimal estimation error rate, optimal regret rate, or the Pareto optimal trade-off between the two objectives. We establish information-theoretical lower bounds that highlight the inherent challenge in estimating dynamic treatment effects and minimizing welfare loss, and also statistically reveal the fundamental trade-off between them.

We consider the estimation of treatment effects in settings when multiple treatments are assigned over time and treatments can have a causal effect on future outcomes. We propose an extension of the double/debiased machine learning framework to estimate the dynamic effects of treatments and apply it to a concrete linear Markovian high-dimensional state space model and to general structural nested mean models. Our method allows the use of arbitrary machine learning methods to control for the high dimensional state, subject to a mean square error guarantee, while still allowing parametric estimation and construction of confidence intervals for the dynamic treatment effect parameters of interest. Our method is based on a sequential regression peeling process, which we show can be equivalently interpreted as a Neyman orthogonal moment estimator. This allows us to show root-n asymptotic normality of the estimated causal effects.

Malaria has been one of the world's deadliest diseases, with approximately 247 million cases and 618

We consider the estimation of treatment effects in settings when multiple treatments are assigned over time and treatments can have a causal effect on future outcomes. We propose an extension of the double/debiased machine learning framework to estimate the dynamic effects of treatments and apply it to a concrete linear Markovian high-dimensional state space model and to general structural nested mean models. Our method allows the use of arbitrary machine learning methods to control for the high dimensional state, subject to a mean square error guarantee, while still allowing parametric estimation and construction of confidence intervals for the dynamic treatment effect parameters of interest. Our method is based on a sequential regression peeling process, which we show can be equivalently interpreted as a Neyman orthogonal moment estimator. This allows us to show root-n asymptotic normality of the estimated causal effects.

Experimentation has been critical and increasingly popular across various domains, such as clinical trials and online platforms, due to its widely recognized benefits. One of the primary objectives of classical experiments is to estimate the average treatment effect (ATE) to inform future decision-making. However, in healthcare and many other settings, treatment effects may be non-stationary, meaning that they can change over time, rendering the traditional experimental design inadequate and the classical static ATE uninformative. In this work, we address the problem of non-stationary experimental design under linear trends by considering two objectives: estimating the dynamic treatment effect and minimizing welfare loss within the experiment. We propose an efficient design that can be customized for optimal estimation error rate, optimal regret rate, or the Pareto optimal trade-off between the two objectives.

I construct and justify confidence intervals for longitudinal causal parameters estimated with machine learning. Longitudinal parameters include long term, dynamic, and mediated effects. I provide a nonasymptotic theorem for any longitudinal causal parameter estimated with any machine learning algorithm that satisfies a few simple, interpretable conditions. The main result encompasses local parameters defined for specific demographics as well as proximal parameters defined in the presence of unobserved confounding. Formally, I prove consistency, Gaussian approximation, and semiparametric efficiency. The rate of convergence is $n^{-1/2}$ for global parameters, and it degrades gracefully for local parameters. I articulate a simple set of conditions to translate mean square rates into statistical inference. A key feature of the main result is a new multiple robustness to ill posedness for proximal causal inference in longitudinal settings.

We propose kernel ridge regression estimators for mediation analysis and dynamic treatment effects over short horizons. We allow treatments, covariates, and mediators to be discrete or continuous, and low, high, or infinite dimensional. We propose estimators of means, increments, and distributions of counterfactual outcomes with closed form solutions in terms of kernel matrix operations. For the continuous treatment case, we prove uniform consistency with finite sample rates. For the discrete treatment case, we prove root-n consistency, Gaussian approximation, and semiparametric efficiency. We conduct simulations then estimate mediated and dynamic treatment effects of the US Job Corps program for disadvantaged youth.

We consider the estimation of treatment effects in settings when multiple treatments are assigned over time and treatments can have a causal effect on future outcomes. We formulate the problem as a linear state space Markov process with a high dimensional state and propose an extension of the double/debiased machine learning framework to estimate the dynamic effects of treatments. Our method allows the use of arbitrary machine learning methods to control for the high dimensional state, subject to a mean square error guarantee, while still allowing parametric estimation and construction of confidence intervals for the dynamic treatment effect parameters of interest. Our method is based on a sequential regression peeling process, which we show can be equivalently interpreted as a Neyman orthogonal moment estimator. This allows us to show root-n asymptotic normality of the estimated causal effects.